Research
"Deciphering the functions of each mammalian gene is one of the most important challenges that the biomedical research community faces in the next few decades"
Genetic, transcriptomic and proteomic data are weekly published by many laboratories in order to explain diseases. However, these data are difficult to interpret, because the exact function of the identified genes/gene products is often not very well known. Genetically-modified mouse models proved to be extremely valuable in defining the function of genes in physiology and in the pathogenesis of diseases. Using gene-targeted mice, we create mouse models to define the genetic basis of physiology, disease mechanisms and biomarkers, as well as innovative therapeutic targets.
PRESENT and FUTURE in the Laboratory of Functional Genetics
Based on our expertise in the construction and phenotypic analysis of mutant mice, we define in vivo the exact function of genes implicated in the control of inositides metabolism and signalling. Previous works have proved that inositol phosphates and phosphoinositides are essential second messengers implicated in many physiological and pathological processes.
We are currently analyzing new mutant mice for genes implicated in angiogenesis, platelet agregation, osteogenesis, kidney development and function, or in hematopoietic cells development and function.
